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In the SUSTAIN program, 83 patients (1.4%) treated with semaglutide developed a gallbladder event, compared with 39 patients (1.9%) in the placebo group ( versus 0.1% with placebo), while the risk of cholecystitis was similar (data derived from the summary of product characteristics (SmPC) (87), as the manuscripts did not describe these data)

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A. V. Arutjunyan, I. G. Popovich, L. S. Kozina, and G. A. Ryzhak, Peptide Regulation of Ageing: From Experiment to Practice, Bentham Science Publishers Ltd., Feb. 2025. doi: 10.2174/0118746098346230250116065407

TEN significantly reduced glial fibrillary acidic protein immunoreactivity and astrocyte activation, implying that its analgesic effects are associated with suppression of spinal astrocytes and neuroinflammation [36, 37]

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